The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
May. 12, 2014
The Regents of the University of California, Oakland, CA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Rafael Bejar, La Jolla, CA (US);
Benjamin Ebert, Brookline, MA (US);
Donna Neuberg, Brookline, MA (US);
Kristen Stevenson, Waltham, MA (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
THE BRIGHAM AND WOMEN'S HOSPITAT . INC, Boston, MA (US);
Abstract
Disclosed are methods for predicting a response of a subject with myelodysplastic syndrome to treatment with a hypomethylating agent, for example using a sample obtained from the subject. The methods can be used to select a subject for treatment with a hypomethylating agent, and/or measure a subject's response to therapy and/or disease progression/regression. The methods include detecting, in a nucleic acid sample obtained from a subject, one or more mutations of any one or more genes selected from Table 3a.