The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Nov. 20, 2019
Applicant:
Codexis, Inc., Redwood City, CA (US);
Inventors:
Gjalt W. Huisman, Redwood City, CA (US);
Nicholas J. Agard, San Francisco, CA (US);
David Elgart, San Mateo, CA (US);
Xiyun Zhang, Fremont, CA (US);
Assignee:
Codexis, Inc., Redwood City, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); A61K 38/51 (2006.01); A61K 31/122 (2006.01); C12P 13/22 (2006.01); C12P 7/42 (2006.01); C12Q 1/527 (2006.01);
U.S. Cl.
CPC ...
C12N 9/88 (2013.01); A61K 31/122 (2013.01); A61K 38/51 (2013.01); C12P 7/42 (2013.01); C12P 13/225 (2013.01); C12Q 1/527 (2013.01); C12Y 403/01023 (2013.01);
Abstract
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.