The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Jan. 13, 2021
Brian Hie, Cambridge, MA (US);
Bonnie Berger Leighton, Newtonville, MA (US);
Bryan D. Bryson, Boston, MA (US);
Brian Hie, Cambridge, MA (US);
Bonnie Berger Leighton, Newtonville, MA (US);
Bryan D. Bryson, Boston, MA (US);
Other;
Abstract
A method of viral escape profiling is used in association with antiviral or vaccine development. The method begins by training a language-based model against training data comprising a corpus of viral protein sequences of a given viral protein to model a viral escape profile. The viral escape profile represents, for one or more regions of the given viral protein, a relative viral escape potential of a mutation, the relative viral escape potential being derived as a function that combines both 'semantic change,' representing a degree to which the mutation is recognized by the human immune system (i.e., antigenic change), and 'grammaticality,' representing a degree to which the mutation affects viral infectivity (i.e. viral fitness). Using the model, a region of the given viral protein having an escape potential of interest is identified. Information regarding the region is then output to a vaccine or anti-viral therapeutic design and development workflow.