The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Sep. 15, 2017
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Jason Eugene Imbriglio, Piscataway, NJ (US);
Whitney Lane Petrilli, Summit, NJ (US);
Yusheng Xiong, Plainsboro, NJ (US);
Zhe Feng, Hillsborough, NJ (US);
Hyewon Youm, Berkeley Heights, NJ (US);
Wonsuk Chang, Princeton, NJ (US);
Rui Liang, East Brunswick, NJ (US);
Zhijian Lu, Plainfield, IN (US);
Jerry Andrew Taylor, Trenton, NJ (US);
Scott B. Hoyt, Arlington, VA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to PCSK9 allosteric binding compounds of Formula I: (Formula (I)) and pharmaceutically acceptable salts thereof, wherein X, X, Y, R, R, R, Rand n are as defined herein. The present invention also relates to compositions which comprise an allosteric binding compound of the invention or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The invention further relates, inter alia, to methods for inducing PCSK9 protein degradation in a subject, and methods for treating atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions, comprising administering to a subject an effective amount of a compound or a pharmaceutically acceptable salt of the invention. The invention also provides a means for the in vitro labeling, detection and/or quantification of PCSK9 in biological samples.