The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 11, 2021
Filed:
Jun. 27, 2018
3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
Agilent Technologies, Inc., Santa Clara, CA (US);
Brian P. Stupi, Cypress, TX (US);
Hong Li, Milwaukee, WI (US);
Weidong Wu, Houston, TX (US);
Megan N. Hersh, Houston, TX (US);
David Hertzog, Houston, TX (US);
Sidney E. Morris, Houston, TX (US);
Michael L. Metzker, Houston, TX (US);
Agilent Technologies, Inc., Santa Clara, CA (US);
Abstract
The present invention relates generally to 3'-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.