The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
Oct. 21, 2016
Shangyu Nhu Biological Chemical Co., Ltd., Shangyu, CN;
Zhejiang University, Hangzhou, CN;
Zhejiang Nhu Company Ltd., Shaoxing, CN;
Hongwei Yu, Hangzhou, CN;
Yong Lv, Shangyu, CN;
Yong Li, Shangyu, CN;
Jianbo Chen, Shangyu, CN;
Shaofeng Chen, Shangyu, CN;
Weifeng Li, Shangyu, CN;
Hongmei Zhang, Shaoxing, CN;
Yongqiang Zhu, Shangyu, CN;
SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD., Shangyu, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
ZHEJIANG NHU COMPANY LTD., Shaoxing, CN;
Abstract
The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0 ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.