The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2021
Filed:
Sep. 28, 2016
Araxes Pharma Llc, San Diego, CA (US);
Liansheng Li, San Diego, CA (US);
Jun Feng, San Diego, CA (US);
Yun Oliver Long, San Diego, CA (US);
Yuan Liu, San Diego, CA (US);
Pingda Ren, San Diego, CA (US);
Yi Liu, San Diego, CA (US);
ARAXES PHARMA LLC, San Diego, CA (US);
Abstract
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer or prodrug thereof, wherein A, B R, R, R, R, R, R, R, G, G, m, m, L, Land E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.