The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2021
Filed:
Aug. 05, 2020
Applicant:
Codexis, Inc., Redwood City, CA (US);
Inventors:
Nicholas J. Agard, San Francisco, CA (US);
Mathew G. Miller, San Carlos, CA (US);
Xiyun Zhang, Fremont, CA (US);
Gjalt W. Huisman, Redwood City, CA (US);
Assignee:
Codexis, Inc., Redwood City, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/24 (2006.01); C12N 15/81 (2006.01); A61K 38/47 (2006.01); C12N 9/40 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/47 (2013.01); A61K 9/0019 (2013.01); C12N 9/2465 (2013.01); C12Y 302/01022 (2013.01);
Abstract
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.