The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 06, 2021

Filed:

May. 02, 2016
Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

Frederick R. Haselton, Nashville, TN (US);

Nicholas M. Adams, Nashville, TN (US);

Steven J. Simmons, Unionville, TN (US);

Elliott P. Dawson, Murfreesboro, TN (US);

Assignees:

VANDERBILT UNIVERSITY, Nashville, TN (US);

BIOVENTURES, INC., Murfreesboro, TN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6818 (2018.01); C12Q 1/68 (2018.01); B01L 7/00 (2006.01); C12Q 1/686 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6818 (2013.01); B01L 7/52 (2013.01); C12Q 1/68 (2013.01); C12Q 1/686 (2013.01); C12N 2310/122 (2013.01); C12N 2310/32 (2013.01); C12Q 2525/101 (2013.01); C12Q 2525/113 (2013.01); C12Q 2531/113 (2013.01); C12Q 2537/143 (2013.01); C12Q 2561/113 (2013.01); Y02A 50/30 (2018.01);
Abstract

Systems, methods, and compositions for monitoring and analyzing nucleic acid hybridization state using L-DNA probes are described. The methods include adding L-DNA probes that can be fluorescently detected to a system including D-DNA. The L-DNA probes include primer, target, and antisense nucleotide sequences, and fluorescent dye compounds. The L-DNA probes are particularly useful for monitoring and analyzing various parameters during DNA amplification using the polymerase chain reaction.


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