The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 30, 2021

Filed:

Jun. 29, 2016
Applicants:

The General Hospital Corporation, Boston, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

David T. Scadden, Weston, MA (US);

Lev Silberstein, Brookline, MA (US);

Peter Kharchenko, Brookline, MA (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 35/14 (2015.01); A61K 35/28 (2015.01); A61K 35/50 (2015.01); A61K 39/395 (2006.01); C12N 5/0789 (2010.01); A61K 9/00 (2006.01); A61K 35/51 (2015.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 9/0019 (2013.01); A61K 35/14 (2013.01); A61K 35/28 (2013.01); A61K 35/50 (2013.01); A61K 35/51 (2013.01); A61K 39/395 (2013.01); A61K 45/06 (2013.01); C12N 5/0647 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01);
Abstract

Disclosed herein are methods for enhancing hematopoietic reconstitution of a subject. One method involves administering a therapeutically effective amount of an inhibitor of Embigin to a recipient subject and can also optionally include administering hematopoietic stem/progenitor cells to the subject. Another method involves administering an inhibitor of Embigin to a donor prior to harvest of hematopoietic stem/progenitor cells. Pharmaceutical compositions relating to the methods are also described.


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