The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Jun. 17, 2016
Robert D. Bowles, Salt Lake City, UT (US);
Niloofar Farhang, Salt Lake City, UT (US);
Joshua Stover, Salt Lake City, UT (US);
Lori Setton, Durham, NC (US);
Farshid Guilak, Durham, NC (US);
Charles Gersbach, Durham, NC (US);
Jonathan Brunger, Durham, NC (US);
Robert D. Bowles, Salt Lake City, UT (US);
Niloofar Farhang, Salt Lake City, UT (US);
Joshua Stover, Salt Lake City, UT (US);
Lori Setton, Durham, NC (US);
Farshid Guilak, Durham, NC (US);
Charles Gersbach, Durham, NC (US);
Jonathan Brunger, Durham, NC (US);
UNIVERSITY OF UTAH RESEARCH FOUNDATION, Salt Lake City, UT (US);
DUKE UNIVERSITY, Durham, NC (US);
Abstract
Described herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of a gene in a cell using said compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising said compositions, inducing site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein.