The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Apr. 07, 2016
Pharmazell Gmbh, Raubling, DE;
Dirk Weuster-Botz, Munich, DE;
Michael Braun, Bad Mergentheim-Edelfingen, DE;
Arno Aigner, Tuntenhausen, DE;
Boqiao Sun, Munich, DE;
Christina Kantzow, Munich, DE;
Sven Bresch, Munich, DE;
Daniel Bakonyi, Cologne, DE;
Werner Hummel, Titz, DE;
Pharmazell GmbH, Raubling, DE;
Abstract
The invention relates to novel 7ß-hydroxysteroid dehydrogenase mutants, to the sequences which encode these enzyme mutants, to processes for the preparation of the enzyme mutants and to their use in enzymatic reactions of cholic acid compounds, in particular in the preparation of ursodeoxycholic acid (UDCS). The invention also relates to novel processes for the synthesis of UDCS using the enzyme mutants; and to the preparation of UDCS using recombinant, multiply-modified microorganisms.