The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2021
Filed:
Apr. 03, 2018
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Albert Einstein College of Medicine, Inc., Bronx, NY (US);
Victoria Link Limited, Wellington, NZ;
Charles R. Esther, Jr., Chapel Hill, NC (US);
Michael R. Knowles, Chapel Hill, NC (US);
Wanda Kay O'Neal, Cary, NC (US);
Deepika Polineni, Kansas City, MI (US);
Steven Isaacman, Oak Beach, NY (US);
Andrew B. Mahon, New York, NY (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Albert Einstein College of Medicine, Inc., Bronx, NY (US);
Victoria Link Limited, Wellington, NZ;
Abstract
This invention relates generally to the use of 5'-methylthioadenosine phosphorylase (MTAP) inhibitors for the treatment of lung diseases associated with inflammation, such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Small molecule inhibitors of MTAP can sustain accumulation of endogenous MTA to therapeutically beneficial levels resulting in decreased inflammation in CF and COPD.