The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2021
Filed:
Oct. 07, 2016
Applicant:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Adam Mullick, Carlsbad, CA (US);
Mark J. Graham, San Clemente, CA (US);
Punit P. Seth, Carlsbad, CA (US);
Susan M. Freier, San Diego, CA (US);
Assignee:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/712 (2006.01); A61K 31/7125 (2006.01); C07H 21/00 (2006.01); C12N 15/113 (2010.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61P 9/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/712 (2013.01); A61P 9/12 (2018.01); C07H 21/00 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12N 15/113 (2013.01);
Abstract
Disclosed herein are compositions and compounds comprising modified oligonucleotides for modulating AGT and modulating a RAAS pathway related disease, disorder and/or condition in an individual in need thereof. A RAAS pathway related disease, disorder and/or condition in an individual such as hypertension can be treated, ameliorated, delayed or prevented with the administration of antisense compounds targeted to AGT.