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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10906944 B1

PDFFull Text
Date of Patent:
Feb. 02, 2021

Filed:

Sep. 14, 2020

Stabilized coronavirus spike (s) protein immunogens and related vaccines

Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Linling He, San Diego, CA (US);

Jiang Zhu, San Diego, CA (US);

Ian A. Wilson, La Jolla, CA (US);

Assignee:

The Scripps Research Institute, La Jolla, CA (US);

Attorneys:

Hugh Wang

Thomas Fitting

Primary Examiner:

Stacy B Chen

Int. Cl.
CPC ...
C07K 14/005 (2006.01); A61P 31/14 (2006.01); A61K 39/215 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/215 (2013.01); A61P 31/14 (2018.01); C12N 7/00 (2013.01); A61K 2039/57 (2013.01); A61K 2039/575 (2013.01); C12N 2770/20022 (2013.01); C12N 2770/20034 (2013.01);
Abstract

The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Find Patent Forward Citations

He, Linling. (2021). Stabilized coronavirus spike (s) protein immunogens and related vaccines (U.S. Patent No. 10906944). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10906944

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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