The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2021
Filed:
Feb. 27, 2018
Applicant:
Beigene, Ltd., Grand Cayman, KY;
Inventors:
Assignee:
BEIGENE, LTD., Grand Cayman, KY;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/22 (2006.01); A61K 31/55 (2006.01); A61P 35/00 (2006.01); C07D 471/22 (2006.01);
U.S. Cl.
CPC ...
C07D 471/22 (2013.01); A61P 35/00 (2018.01); C07B 2200/13 (2013.01);
Abstract
Disclosed herein are salts of (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.