The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Oct. 03, 2017
Danisco Us Inc., Palo Alto, CA (US);
Vtt Technical Research Centre of Finland Ltd., Espoo, FI;
Michael Ward, Palo Alto, CA (US);
Yun Luo, Glen Mills, CA (US);
Felipe Oseas Bendezu, Chadds Ford, PA (US);
Mari Valkonen, Nahkela, FI;
Markku Saloheimo, Helsinki, FI;
Nina Aro, Porvoo, FI;
Tiina Pakula, Espoo, FI;
DANISCO US INC, Palo Alto, CA (US);
VTT TECHNICAL RESEARCH CENTRE OF FINLAND LTD, Espoo, FI;
Abstract
Certain embodiments of the disclosure are directed to variant filamentous fungal cells, compositions thereof and methods thereof for increased production of one or more proteins of interest. More particularly, in certain embodiments, the disclosure is directed to variant filamentous fungal (host) cells derived from parental filamentous fungal cells, wherein the variant host cells comprise a genetic modification which enables the expression/production of a protein of interest (POI) in the absence of inducing substrate. In certain embodiments, a variant fungal host cell of the disclosure comprises a genetic modification which increases the expression of a variant activator of cellulase expression 3 (ace3) gene encoding an Ace3 protein referred to herein as Ace3-L.