The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 22, 2020

Filed:

Sep. 28, 2018
Applicant:

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Armon R. Sharei, Watertown, MA (US);

Viktor A. Adalsteinsson, Kennett Square, PA (US);

Nahyun Cho, Closter, NJ (US);

Robert S. Langer, Newton, MA (US);

J. Christopher Love, Somerville, MA (US);

Klavs F. Jensen, Lexington, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); C12N 5/09 (2010.01); C12N 5/078 (2010.01); G01N 15/14 (2006.01); C12Q 1/04 (2006.01); G01N 33/574 (2006.01); G01N 1/30 (2006.01); G01N 15/10 (2006.01); B82Y 30/00 (2011.01); G01N 15/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502761 (2013.01); C12N 5/0634 (2013.01); C12N 5/0693 (2013.01); C12Q 1/04 (2013.01); G01N 15/1459 (2013.01); G01N 15/1484 (2013.01); G01N 33/574 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/08 (2013.01); B01L 2400/0487 (2013.01); B82Y 30/00 (2013.01); G01N 1/30 (2013.01); G01N 2015/0065 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1081 (2013.01);
Abstract

Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.


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