The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 24, 2020

Filed:

Jan. 05, 2018
Applicant:

Illumina, Inc., San Diego, CA (US);

Inventors:

Kevin Wu, San Diego, CA (US);

Chen Zhao, San Diego, CA (US);

Han-Yu Chuang, San Diego, CA (US);

Alex So, San Diego, CA (US);

Stephen Tanner, San Diego, CA (US);

Stephen M. Gross, San Diego, CA (US);

Assignee:

Illumina, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); G01N 33/50 (2006.01); C12Q 1/6869 (2018.01); C12Q 1/6855 (2018.01); G16B 25/00 (2019.01); G16B 30/00 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C12Q 1/6855 (2013.01); G16B 25/00 (2019.02); G16B 30/00 (2019.02);
Abstract

The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length. In some implementations, the unique molecular index sequences include variable-length nonrandom sequences. In some implementations, the unique molecular index sequences are associated with the individual polynucleotide fragments based on alignment scores indicating similarity between the unique molecular index sequences and subsequences of sequence reads obtained from the individual polynucleotide fragments. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.


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