The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Sep. 01, 2015
Institute of Biotechnology, Academy of Military Medical Sciences, China, Beijing, CN;
Jun Wu, Beijing, CN;
Chao Pan, Beijing, CN;
Peng Sun, Beijing, CN;
Hengliang Wang, Beijing, CN;
Bo Liu, Beijing, CN;
Zhehui Peng, Beijing, CN;
Li Zhu, Beijing, CN;
Shaohong Chang, Beijing, CN;
Xin Gong, Beijing, CN;
Erling Feng, Beijing, CN;
Bin Wang, Beijing, CN;
Ming Zeng, Beijing, CN;
Abstract
The invention provided a method for preparing a bacterial polysaccharide-modified recombinant fusion protein and use of the bacterial polysaccharide-modified recombinant fusion protein. The method comprises: co-expressing a recombinant fusion protein and theO-oligosaccharyltransferase PglL in an O-antigen ligase gene-defective bacterium, and linking a polysaccharides endogenous or exogenous for the bacterium to the recombinant fusion protein by the O-oligosaccharyltransferase PglL, to obtain the bacterial polysaccharide-modified recombinant fusion protein. The protein can be used for preparing antibodies against bacterial polysaccharides and vaccines.