The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Jul. 21, 2017
Instytut Farmakologii Polskiej Akademii Nauk, Cracow, PL;
Adam Hogendorf, Cracow, PL;
Agata Hogendorf, Cracow, PL;
Grzegorz Satala, Cracow, PL;
Rafal Kurczab, Tarnow, PL;
Ryszard Bugno, Cracow, PL;
Jakub Staron, Cracow, PL;
Tomasz Lenda, Cracow, PL;
Andrzej J Bojarski, Zabierzow, PL;
INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK, Cracow, PL;
Abstract
The invention relates to a new class of substituted indole derivatives that are able to activate 5-HTserotonin receptor. These compounds bind 5-HTserotonin receptor with high affinity and selectivity, while possessing favourable physicochemical properties. The compounds of the invention are the first described low-basicity 5-HTreceptor agonists. The invention also relates to use of such compounds in the treatment or prevention of 5-HTreceptor-related disorders, especially of the central nervous system. The invention also relates to the isotopically labelled compounds for use in the in vivo diagnostics or imaging of a 5-HTserotonin receptor.