The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Nov. 08, 2018
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Bert Vogelstein, Baltimore, MD (US);
Frank Diehl, Baltimore, MD (US);
Kenneth W. Kinzler, Baltimore, MD (US);
Meng Li, San Francisco, CA (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6858 (2018.01); H02H 1/00 (2006.01); H02H 3/33 (2006.01); G01R 31/50 (2020.01); G01R 31/327 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6858 (2013.01); G01R 31/3277 (2013.01); G01R 31/50 (2020.01); H02H 1/0015 (2013.01); H02H 3/33 (2013.01);
Abstract
Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.