The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Aug. 13, 2012
Claire Ashman, Stevenage, GB;
Mary Birchler, King of Prussia, PA (US);
Rudolf M. T. DE Wildt, Stevenage, GB;
Claire Holland, King of Prussia, PA (US);
Alan Peter Lewis, Stevenage, GB;
Peter Morley, Stevenage, GB;
Thomas Sandal, Stevenage, GB;
Michael Steward, Stevenage, GB;
Claire Ashman, Stevenage, GB;
Mary Birchler, King of Prussia, PA (US);
Rudolf M. T. De Wildt, Stevenage, GB;
Claire Holland, King of Prussia, PA (US);
Alan Peter Lewis, Stevenage, GB;
Peter Morley, Stevenage, GB;
Thomas Sandal, Stevenage, GB;
Michael Steward, Stevenage, GB;
Glaxo Group Limited, Brentford, Middlesex, unknown;
Abstract
The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.