The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2020
Filed:
Dec. 23, 2016
Genentech, Inc., South San Francisco, CA (US);
Newlink Genetics Corporation, Ames, IA (US);
Xingyu Lin, Beijing, CN;
Po-wai Yuen, Beijing, CN;
Rohan Mendonca, South San Francisco, CA (US);
Brendan Parr, South San Francisco, CA (US);
Richard Pastor, South San Francisco, CA (US);
Zhonghua Pei, South San Francisco, CA (US);
Lewis Gazzard, South San Francisco, CA (US);
Firoz Jaipuri, Ames, IA (US);
Sanjeev Kumar, Ames, IA (US);
Xiaokai Li, Ames, IA (US);
Roheeth Pavana, Ames, IA (US);
Hima Potturi, Ames, IA (US);
Venkata Velvadapu, Ames, IA (US);
Jesse Waldo, Ames, IA (US);
Zuhui Zhang, Ames, IA (US);
Guosheng Wu, Beijing, CN;
Benjamin Douglas Sellers, South San Francisco, CA (US);
Genentech, Inc., South San Francisco, CA (US);
NewLink Genetics Corporation, Ames, IA (US);
Abstract
Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.