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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10793861 B1

PDFFull Text
Date of Patent:
Oct. 06, 2020

Filed:

Jul. 20, 2018

Products and methods for treatment of familial amyotrophic lateral sclerosis

Applicants:

Research Institute AT Nationwide Children's Hospital, Columbus, OH (US);

Ludwig Institute for Cancer Research, Zurich, CH;

Inventors:

Brian K. Kaspar, Columbus, OH (US);

Kevin Foust, Columbus, OH (US);

Don W. Cleveland, La Jolla, CA (US);

Assignees:

RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US);

LUDWIG INSTITUTE FOR CANCER RESEARCH, Zurich, CH;

Attorney:

Marshall, Gerstein & Borun LLP

Primary Examiner:

Robert M Kelly

Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 31/7105 (2006.01); A61K 9/00 (2006.01); C12N 15/86 (2006.01); C12N 7/00 (2006.01); C12N 9/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 9/0019 (2013.01); A61K 31/7105 (2013.01); C12N 7/00 (2013.01); C12N 9/0089 (2013.01); C12N 15/86 (2013.01); C12Y 115/01001 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/32 (2013.01); C12N 2750/14043 (2013.01); C12N 2750/14143 (2013.01);
Abstract

The present invention relates to RNA-based methods for inhibiting the expression of the superoxide dismutase 1 (SOD-1) gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding RNAs that knock down the expression of SOD-1. The methods have application in the treatment of amyotrophic lateral sclerosis.

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Kaspar, Brian. (2020). Products and methods for treatment of familial amyotrophic lateral sclerosis (U.S. Patent No. 10793861). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10793861

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