The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 06, 2020

Filed:

Aug. 29, 2018
Applicant:

Novartis Ag, Basel, CH;

Inventors:

Jeremy Lee Baryza, Cambridge, MA (US);

Rohan Eric John Beckwith, Cambridge, MA (US);

Keith Bowman, Cambridge, MA (US);

Crystal Byers, Cambridge, MA (US);

Tanzina Fazal, Cambridge, MA (US);

Gabriel Grant Gamber, Cambridge, MA (US);

Cameron Chuck-Munn Lee, Cambridge, MA (US);

Ritesh Bhanudasji Tichkule, Cambridge, MA (US);

Chandra Vargeese, Cambridge, MA (US);

Shuangxi Wang, Cambridge, MA (US);

Laura West, Cambridge, MA (US);

Thomas Zabawa, Cambridge, MA (US);

Junping Zhao, Cambridge, MA (US);

Assignee:

NOVARTIS AG, Basel, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/18 (2017.01); A61K 9/127 (2006.01); A61K 9/51 (2006.01); A61K 31/713 (2006.01); C07C 217/58 (2006.01); C07C 219/06 (2006.01); C07C 229/12 (2006.01); C07D 317/28 (2006.01); C07D 295/096 (2006.01); A61K 9/00 (2006.01); A61K 38/22 (2006.01); A61K 47/22 (2006.01); C07C 229/14 (2006.01); C07C 235/42 (2006.01); C07D 205/04 (2006.01); C07D 213/69 (2006.01); C07D 213/79 (2006.01); C12N 15/113 (2010.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/18 (2013.01); A61K 9/0019 (2013.01); A61K 9/1272 (2013.01); A61K 9/5123 (2013.01); A61K 31/713 (2013.01); A61K 38/2264 (2013.01); A61K 47/22 (2013.01); C07C 217/58 (2013.01); C07C 219/06 (2013.01); C07C 229/12 (2013.01); C07C 229/14 (2013.01); C07C 235/42 (2013.01); C07D 205/04 (2013.01); C07D 213/69 (2013.01); C07D 213/79 (2013.01); C07D 295/096 (2013.01); C07D 317/28 (2013.01); C12N 15/113 (2013.01); A61K 48/00 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.


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