The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2020
Filed:
Apr. 04, 2014
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Mohammad Haris, Philadelphia, PA (US);
Anup Singh, Philadelphia, PA (US);
Kejia Cai, Elkins Park, PA (US);
Ravinder Reddy, Gladwyne, PA (US);
Feliks Kogan, Philadelphia, PA (US);
Ravi Prakash Reddy Nanga, Philadelphia, PA (US);
Hari Hariharan, Mount Laurel, NJ (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
A non-invasive imaging approach using CEST and MRS may be used to monitor the cleavage of the poly-L-glutamate (PLG) backbone. The cleavage of PLG by cathespsin B can expose exchangeable —NH2 protons in the PLG that are then monitored non-invasively through CEST. The technique can provide direct information on malignant tissue and tumor aggressiveness, and can also be used to monitor treatment.