The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 29, 2020

Filed:

May. 11, 2016
Applicants:

Illumina, Inc., San Diego, CA (US);

The Regents of the University of California, Oakland, CA (US);

Inventors:

Kevin L Gunderson, Encinitas, CA (US);

Jingwei Bai, San Diego, CA (US);

Cheng-Yao Chen, Eugene, OR (US);

Jeffrey G Mandell, San Diego, CA (US);

Sergio Peisajovich, San Diego, CA (US);

Philip G Collins, Oakland, CA (US);

Gregory A Weiss, Oakland, CA (US);

Boyan Boyanov, San Diego, CA (US);

Assignees:

ILLUMINA, INC., San Diego, CA (US);

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C12Q 1/6869 (2013.01); C12Q 2521/543 (2013.01); C12Q 2565/607 (2013.01);
Abstract

The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.


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