The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2020
Filed:
Sep. 07, 2015
Institute of Biotechnology, Academy of Military Medical Sciences, China, Beijing, CN;
Jun Wu, Beijing, CN;
Hengliang Wang, Beijing, CN;
Peng Sun, Beijing, CN;
Bo Liu, Beijing, CN;
Li Zhu, Beijing, CN;
Chao Pan, Beijing, CN;
Tiantian Wang, Beijing, CN;
Xin Gong, Beijing, CN;
Shaohong Chang, Beijing, CN;
Erling Feng, Beijing, CN;
Abstract
The present invention discloses aA with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of aA strain to obtain aA with deletion of cld gene; allowing overexpression of cldgene encoding an enzyme controlling chain length of O-antigen ofinA deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of theA O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB4573-OPSand rEPA4573-OPSas prepared by usingA with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies againstA, and their antibody titers are significantly improved.