The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 22, 2020

Filed:

Feb. 03, 2017
Applicants:

The Regents of the University of California, Oakland, CA (US);

U.s. Government Represented BY the Department of Veterans Affairs, Washington, DC (US);

Inventors:

Leonard H. Rome, Los Angeles, CA (US);

Valerie A. Kickhoefer, Sherman Oaks, CA (US);

Steven M. Dubinett, Los Angeles, CA (US);

Sherven Sharma, Oakland, CA (US);

Upendra K. Kar, Oakland, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); C07K 14/52 (2006.01); A61K 38/45 (2006.01); C12N 9/10 (2006.01); C12N 9/96 (2006.01); C12N 15/86 (2006.01); A61K 47/69 (2017.01); A61K 38/00 (2006.01); A61K 35/12 (2015.01); A61K 48/00 (2006.01); C07H 21/00 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); C12N 5/0783 (2010.01); G01N 33/535 (2006.01);
U.S. Cl.
CPC ...
A61K 38/195 (2013.01); A61K 38/00 (2013.01); A61K 38/45 (2013.01); A61K 47/6921 (2017.08); C07K 14/521 (2013.01); C12N 9/1077 (2013.01); C12Y 204/0203 (2013.01); A61K 35/12 (2013.01); A61K 48/00 (2013.01); C07H 21/00 (2013.01); C07K 7/06 (2013.01); C07K 14/47 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01); C12N 5/0636 (2013.01); C12N 9/96 (2013.01); C12N 15/86 (2013.01); G01N 33/535 (2013.01);
Abstract

The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.


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