The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Sep. 08, 2016
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Michael Ohlmeyer, Plainsboro, NJ (US);
Nilesh Zaware, Briarwood, NY (US);
Assignee:
Ichan School of Medicine at Mount Sinai, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 401/04 (2006.01); C07D 498/04 (2006.01); C07D 403/04 (2006.01); C07D 405/04 (2006.01);
U.S. Cl.
CPC ...
C07D 413/04 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 405/04 (2013.01); C07D 413/14 (2013.01); C07D 498/04 (2013.01);
Abstract
A genus of arylsulfonamide derivatives of heterocyclic constrained tricyclic compounds is disclosed. The compounds are of the following genus: The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a therapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.