The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Feb. 14, 2020
Applicant:
Precision Biosciences, Inc., Durham, NC (US);
Inventors:
Victor Bartsevich, Durham, NC (US);
Derek Jantz, Durham, NC (US);
James Jefferson Smith, Morrisville, NC (US);
Michael G. Nicholson, Chapel Hill, NC (US);
Assignee:
Precision BioSciences, Inc., Durham, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); C12N 15/55 (2006.01); C12N 15/861 (2006.01); A61K 38/46 (2006.01); C12N 15/52 (2006.01); C12N 15/90 (2006.01); A61P 27/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/465 (2013.01); C12N 9/22 (2013.01); C12N 15/52 (2013.01); C12N 15/861 (2013.01); C12N 15/907 (2013.01); A61P 27/00 (2018.01); C12N 2750/14143 (2013.01);
Abstract
Disclosed are recombinant meganucleases engineered to recognize and cleave recognition sequences present in a mutant RHO P23H allele. The invention further relates to the use of such recombinant meganucleases in methods for treating retinitis pigmentosa, wherein the mutant RHO P23H allele is preferentially targeted, cleaved, and inactivated.