The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 28, 2020

Filed:

Aug. 18, 2017
Applicant:

University of Florida Research Foundation, Incorporated, Gainesville, FL (US);

Inventors:

Li Zhong, Gainesville, FL (US);

Sergei Zolotukhin, Gainesville, FL (US);

Lakshmanan Govindasamy, Gainesville, FL (US);

Mavis Agbandje-McKenna, Gainesville, FL (US);

Arun Srivastava, Gainesville, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/005 (2006.01); C12N 15/86 (2006.01); A61K 48/00 (2006.01); A61K 39/00 (2006.01); C12N 15/864 (2006.01); A61K 35/76 (2015.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 35/76 (2013.01); A61K 39/0011 (2013.01); A61K 48/005 (2013.01); A61K 48/0008 (2013.01); A61K 48/0091 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 15/8645 (2013.01); A61K 2039/5158 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14142 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14145 (2013.01); C12N 2750/14171 (2013.01); C12N 2810/6027 (2013.01);
Abstract

Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors.


Find Patent Forward Citations

Loading…