The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Oct. 22, 2015
Applicant:
Ucb Biopharma Srl, Brussels, BE;
Inventors:
James Philip O'Connell, Slough, GB;
John Robert Porter, Slough, GB;
Alastair Lawson, Slough, GB;
Boris Kroeplien, Slough, GB;
Stephen Edward Rapecki, Slough, GB;
Timothy John Norman, Slough, GB;
Graham John Warrellow, Slough, GB;
Assignee:
UCB BIOPHARMA SRL, Brussels, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); C07K 14/525 (2006.01); C07K 14/705 (2006.01); C07K 16/24 (2006.01); A61K 47/64 (2017.01); A61P 37/00 (2006.01); C07D 401/14 (2006.01); C07D 471/00 (2006.01); C07D 213/72 (2006.01); C07D 235/04 (2006.01); C07D 239/26 (2006.01); C07D 471/04 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6845 (2013.01); A61K 47/6425 (2017.08); A61P 35/00 (2018.01); A61P 37/00 (2018.01); C07D 213/72 (2013.01); C07D 235/04 (2013.01); C07D 239/26 (2013.01); C07D 401/14 (2013.01); C07D 471/00 (2013.01); C07D 471/04 (2013.01); C07K 14/525 (2013.01); C07K 14/70575 (2013.01); C07K 16/241 (2013.01); G01N 33/6854 (2013.01); G01N 33/6863 (2013.01); C07K 2317/55 (2013.01); C07K 2317/92 (2013.01); G01N 2333/525 (2013.01); G01N 2500/02 (2013.01);
Abstract
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.