The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2020

Filed:

Jun. 10, 2016
Applicant:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

Peter Hammerman, Newton, MA (US);

Kwok-kin Wong, Arlington, MA (US);

Nathanael S. Gray, Boston, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/52 (2006.01); A61K 31/551 (2006.01); A61K 31/5517 (2006.01); A61K 31/69 (2006.01); A61P 35/00 (2006.01); A61K 31/4162 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/4162 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 31/53 (2013.01); A61K 31/551 (2013.01); A61K 31/5517 (2013.01); A61K 31/69 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract

The present disclosure provides combination therapy of a transcription inhibitor and a kinase inhibitor. The combination of the transcription inhibitor and the kinase inhibitor may be useful in treating and/or preventing in a subject a proliferative disease, such as proliferative a disease that is resistant to the transcription inhibitor alone or the kinase inhibitor alone. In certain embodiments, the proliferative disease is a cancer. The combination of the transcription inhibitor and the kinase inhibitor is expected to be synergistic.


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