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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10695446 B1

PDFFull Text
Date of Patent:
Jun. 30, 2020

Filed:

May. 02, 2016

Composition and method for detecting hypoxia

Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

Imam Uddin, Nashville, TN (US);

Ashwath Jayagopal, Nashville, TN (US);

Jashim Uddin, Nashville, TN (US);

John S. Penn, Brentwood, TN (US);

Lawrence J. Marnett, Nashville, TN (US);

Assignee:

Vanderbilt University, Nashville, TN (US);

Attorneys:

Stites & Harbison PLLC

Mandy Wilson Decker

Primary Examiner:

Michael G Hartley

Assistant Examiner:

Melissa J Perreira

Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61B 10/00 (2006.01); A61K 49/00 (2006.01); A61K 31/4545 (2006.01); A61K 31/05 (2006.01); A61K 31/19 (2006.01); A61K 31/4178 (2006.01); C07D 493/16 (2006.01); C07D 403/14 (2006.01); A61K 31/4375 (2006.01); A61K 31/045 (2006.01); C07D 405/14 (2006.01); G01N 33/50 (2006.01); C07D 487/22 (2006.01); A61K 45/06 (2006.01); C12Q 1/26 (2006.01); G01N 33/52 (2006.01); A61P 27/02 (2006.01); A61P 43/00 (2006.01); A61K 31/454 (2006.01); A61K 31/517 (2006.01); A61K 31/58 (2006.01); C09B 62/343 (2006.01); C09B 62/78 (2006.01); C09K 11/06 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0052 (2013.01); A61K 31/045 (2013.01); A61K 31/05 (2013.01); A61K 31/19 (2013.01); A61K 31/4178 (2013.01); A61K 31/4375 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/517 (2013.01); A61K 31/58 (2013.01); A61K 45/06 (2013.01); A61K 49/0021 (2013.01); A61K 49/0023 (2013.01); A61K 49/0032 (2013.01); A61K 49/0041 (2013.01); A61P 27/02 (2018.01); A61P 43/00 (2018.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 487/22 (2013.01); C07D 493/16 (2013.01); C09B 62/3435 (2013.01); C09B 62/78 (2013.01); C09K 11/06 (2013.01); C12Q 1/26 (2013.01); G01N 33/50 (2013.01); G01N 33/52 (2013.01); A61K 49/0017 (2013.01); C09K 2211/1018 (2013.01); G01N 2800/7038 (2013.01);
Abstract

A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims-and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.

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