The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Aug. 18, 2016
Jinan University, Guangdong, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Pudong Shanghai, CN;
Ke Ding, Guangdong, CN;
Meiyu Geng, Guangdong, CN;
Li Tan, Guangdong, CN;
Jian Ding, Guangdong, CN;
Zhang Zhang, Guangdong, CN;
Jing Ai, Guangdong, CN;
Xiaomei Ren, Guangdong, CN;
Donglin Gao, Guangdong, CN;
Zhengchao Tu, Guangdong, CN;
Xiaoyun Lu, Guangdong, CN;
Dongmei Zhang, Guangdong, CN;
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD., Shanghai, CN;
JINAN UNIVERSITY, Guangdong, CN;
SHANGHAI INTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Pudong, Shanghai, CN;
Abstract
Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.