The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2020
Filed:
Nov. 19, 2018
Applicant:
The Chinese University of Hong Kong, Shatin, N.T. Hong Kong SAR, CN;
Inventors:
Kenneth Ka Ho Lee, Tai Po, CN;
Tommy Lok Man Lo, Shatin, CN;
Hoi Hung Cheung, Tsz Wan Shan, CN;
Wai Yee Chan, Ma On Shan, CN;
Assignee:
The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); C12N 2500/40 (2013.01); C12N 2501/999 (2013.01); C12N 2506/1307 (2013.01); C12N 2506/1392 (2013.01); C12N 2527/00 (2013.01);
Abstract
The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).