The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2020
Filed:
Feb. 26, 2018
Applicant:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Gregory Hinkle, Cambridge, MA (US);
Victor Kotelianski, Cambridge, MA (US);
Brian Bettencourt, Cambridge, MA (US);
Alfica Sehgal, Cambridge, MA (US);
Tatiana Novobrantseva, Cambridge, MA (US);
Assignee:
ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C07H 21/02 (2006.01); C07K 14/495 (2006.01); C07K 14/78 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); C07K 14/4705 (2013.01); C07K 14/495 (2013.01); C07K 14/78 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01);
Abstract
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the COL1A1, TGF-β, and SMAD2/3 genes, and methods of using such dsRNA compositions to inhibit expression of COL1A1, TGF-β, and SMAD2/3.