The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Jun. 20, 2016
Precision Biosciences, Inc., Durham, NC (US);
Derek Jantz, Durham, NC (US);
James Jefferson Smith, Morrisville, NC (US);
Michael G. Nicholson, Chapel Hill, NC (US);
Derek Jantz, Durham, NC (US);
James Jefferson Smith, Morrisville, NC (US);
Michael G. Nicholson, Chapel Hill, NC (US);
Precision BioSciences, Inc., Durham, NC (US);
Abstract
Disclosed herein are viral vectors for use in recombinant molecular biology techniques. In particular, the present disclosure relates to self-limiting viral vectors comprising genes encoding site-specific endonucleases as well as recognition sequences for site-specific endonucleases such that expression of the endonuclease in a cell cleaves the viral vector and limits its persistence time. In some embodiments, the viral vectors disclosed herein also carry directives to delete, insert, or change a target sequence.