The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2020
Filed:
Aug. 23, 2017
Shire Human Genetic Therapies, Inc., Lexington, MA (US);
Nazila Salamat-Miller, Arlington, MA (US);
Katherine Taylor, Arlington, MA (US);
Paul Campolieto, Charlottesville, VA (US);
Zahra Shahrokh, Weston, MA (US);
Jing Pan, Boxborough, MA (US);
Lawrence Charnas, Natick, MA (US);
Teresa Leah Wright, Lexington, MA (US);
Pericles Calias, Melrose, MA (US);
Shire Human Genetic Therapies, Inc., Lexington, MA (US);
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.