The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2020
Filed:
Jun. 06, 2018
Applicant:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Inventors:
Gerald J. Tanoury, Marlborough, MA (US);
William Aloysius Nugent, Manomet, MA (US);
Vadims Dvornikovs, Lancaster, MA (US);
Peter Jamison Rose, Littleton, MA (US);
Assignee:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/506 (2006.01); B01J 31/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/506 (2013.01); B01J 31/04 (2013.01); B01J 2231/44 (2013.01); B01J 2531/824 (2013.01);
Abstract
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.