The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10633713 B1

PDF
Full Text
Expired
Date of Patent:
Apr. 28, 2020

Filed:

Jan. 25, 2018
Applicants:

The Chinese University of Hong Kong Office of Research and Knowledge Transfer Services, Shatin, HK;

Grail, Inc., Menlo Park, CA (US);

Inventors:

Yuk-Ming Dennis Lo, Homantin, CN;

Rossa Wai Kwun Chiu, Shatin, CN;

Kwan Chee Chan, Shatin, CN;

Peiyong Jiang, Shatin, CN;

Wai Kei Lam, Kowloon, CN;

Assignees:

The Chinese University of Hong Kong, Shatin, New Territories, HK;

GRAIL, Inc., Menlo Park, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6888 (2018.01); C12Q 1/6879 (2018.01); C12Q 1/6806 (2018.01); C12Q 1/6886 (2018.01); C12Q 1/686 (2018.01); G16B 20/00 (2019.01); G16H 10/40 (2018.01); G16H 50/20 (2018.01); G16H 50/70 (2018.01); G16B 30/10 (2019.01); G16H 50/30 (2018.01); G16B 40/00 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/6888 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6879 (2013.01); C12Q 1/6886 (2013.01); G16B 20/00 (2019.02); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/166 (2013.01); G16B 30/10 (2019.02); G16B 40/00 (2019.02); G16H 10/40 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G16H 50/70 (2018.01); Y02A 90/26 (2018.01);
Abstract

Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).


Find Patent Forward Citations

Lo, Yuk-Ming. (2020). Diagnostic applications using nucleic acid fragments (U.S. Patent No. 10633713). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10633713

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