The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Aug. 15, 2016
Applicant:
William Marsh Rice University, Houston, TX (US);
Inventors:
Ramon Gonzalez, Houston, TX (US);
James Clomburg, Houston, TX (US);
Clementina Dellomonaco, Wilmington, DE (US);
Elliot N. Miller, Houston, TX (US);
Assignee:
William Marsh Rice University, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 7/16 (2006.01); C12P 5/02 (2006.01); C12P 7/40 (2006.01); C12P 7/04 (2006.01); C12P 7/42 (2006.01); C12P 7/64 (2006.01); C12N 15/70 (2006.01); C12N 9/04 (2006.01); C12N 9/02 (2006.01); C12N 9/10 (2006.01); C12N 9/88 (2006.01);
U.S. Cl.
CPC ...
C12P 7/16 (2013.01); C12N 9/001 (2013.01); C12N 9/0006 (2013.01); C12N 9/1029 (2013.01); C12N 9/88 (2013.01); C12N 15/70 (2013.01); C12P 5/02 (2013.01); C12P 5/026 (2013.01); C12P 7/04 (2013.01); C12P 7/40 (2013.01); C12P 7/42 (2013.01); C12P 7/6409 (2013.01); C12Y 101/01035 (2013.01); C12Y 102/0105 (2013.01); C12Y 103/99003 (2013.01); C12Y 203/01 (2013.01); C12Y 402/01017 (2013.01); Y02E 50/10 (2013.01); Y02P 20/52 (2015.11);
Abstract
The invention relates to recombinant microorganisms that have been engineered to produce various chemicals using genes that have been repurposed to create a reverse beta oxidation pathway. Generally speaking, the beta oxidation cycle is expressed and driven in reverse by modifying various regulation points for as many cycles as needed, and then the CoA thioester intermediates are converted to useful products by the action of termination enzymes.