The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Sep. 09, 2016
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Clark Zhang, Sunnyvale, CA (US);
Panagiotis Mastorakos, Charlottesville, VA (US);
Jung Soo Suk, Baltimore, MD (US);
Justin Hanes, Baltimore, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/14 (2006.01); A61K 9/51 (2006.01); A61K 9/00 (2006.01); A61K 49/00 (2006.01); A61K 47/02 (2006.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5153 (2013.01); A61K 9/0085 (2013.01); A61K 9/5115 (2013.01); A61K 9/5123 (2013.01); A61K 9/5138 (2013.01); A61K 9/5146 (2013.01); A61K 47/02 (2013.01); A61K 49/0032 (2013.01); A61K 49/0093 (2013.01); A61P 25/00 (2018.01);
Abstract
Improved distribution can be achieved by delivering nanoparticles possessing non-adhesive surfaces via CED in a hyperosmolar infusate solution. This delivery strategy minimizes the hindrances imposed by the brain extracellular matrix and reduces the concentration of therapeutic that is confined within perivascular spaces.