The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
Apr. 27, 2017
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Jarrod Dudakov, Seattle, WA (US);
Marcel Van Den Brink, New York, NY (US);
Tobias Wertheimer, Freiburg, DE;
Assignee:
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/03 (2006.01); C12N 5/071 (2010.01); A61K 38/18 (2006.01); C07K 14/51 (2006.01); C07K 14/005 (2006.01); C12N 5/10 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0617 (2013.01); A61K 38/1875 (2013.01); C07K 14/005 (2013.01); C07K 14/51 (2013.01); C12N 5/10 (2013.01); C12N 2501/155 (2013.01); C12N 2710/10322 (2013.01);
Abstract
The present disclosure describes methods to promote thymic regeneration following injury or damage to the thymus by administering to the thymus an effective amount of (1) bone morphogenetic protein 4 (BMP4), (2) thymus-derived endothelial cells that express BMP4 or (3) a combination of BMP4 and BMP4-secreting thymus-derived endothelial cells.