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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10617711 B1

PDFFull Text
Date of Patent:
Apr. 14, 2020

Filed:

Jun. 30, 2015

Antitumor composition based on hyaluronic acid and inorganic nanoparticles, method of preparation thereof and use thereof

Applicant:

Contipro Pharma A.s., DolnĂ­ Dobrouc, CZ;

Inventors:

Daniela Smejkalova, Pisek, CZ;

Kristina Nesporova, Brno, CZ;

Martina Tepla, Policka, CZ;

Jakub Syrovatka, Letohrad, CZ;

Gloria Huerta-Angeles, Ceska Trebova, CZ;

Martina Pospisilova, Olomouc, CZ;

Vit Matuska, Ostrava-Poruba, CZ;

Jiri Mrazek, Zamberk, CZ;

Andrea Galisova, Rybany, SK;

Daniel Jirak, Jesenice, CZ;

Vladimir Velebny, Zamberk, CZ;

Assignee:

Contipro a.s., Dolni Dobrouc, CZ;

Attorney:

Wood Herron & Evans LLP

Primary Examiner:

Abigail Vanhorn

Int. Cl.
CPC ...
A61K 31/728 (2006.01); A61K 9/00 (2006.01); A61P 35/00 (2006.01); A61K 47/36 (2006.01); A61K 9/107 (2006.01); A61K 33/26 (2006.01); A61K 33/30 (2006.01); A61K 49/18 (2006.01); A61K 9/51 (2006.01); A61K 31/337 (2006.01); A61K 41/00 (2020.01); A61K 45/06 (2006.01); A61K 47/02 (2006.01); A61K 49/12 (2006.01); C08B 37/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/728 (2013.01); A61K 9/0019 (2013.01); A61K 9/1075 (2013.01); A61K 9/5115 (2013.01); A61K 9/5123 (2013.01); A61K 31/337 (2013.01); A61K 33/26 (2013.01); A61K 33/30 (2013.01); A61K 41/0057 (2013.01); A61K 45/06 (2013.01); A61K 47/02 (2013.01); A61K 47/36 (2013.01); A61K 49/12 (2013.01); A61K 49/1809 (2013.01); A61K 49/1839 (2013.01); A61K 49/1887 (2013.01); C08B 37/0072 (2013.01);
Abstract

The invention relates to an antitumor composition based on hydrophobized hyaluronan and inorganic nanoparticles stabilized by oleic acid. The hydrophobized hyaluronan in the form of an acylated hyaluronan serves in the composition as a carrier of inorganic nanoparticles. Out of the group of inorganic nanoparticles, the composition may comprise superparamagnetic nanoparticles, nanoparticles of ZnO and moreover, upconversion nanoparticles. Said composition is selectively cytotoxic with respect to both suspension and adherent tumor cell lines, especially with respect to tumor cell lines of colorectum carcinoma and adenocarcinoma, lung carcinoma, hepatocellular carcinoma and breast adenocarcinoma. The highest cytotoxic effects were observed in case of the composition based on an oleyl derivative of hyaluronan with SPIONs. The composition of acylated hyaluronan with SPIONs may also be advantageously used for an in vivo detection of accumulation of the composition in the body, preferably in a tumor or in liver. Said composition is sterilizable in the final package.

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