The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
Jan. 23, 2015
Km Biologics Co., Ltd., Kumamoto, JP;
National University Corporation Kumamoto University, Kumamoto, JP;
Akihiko Hosoi, Kumamoto, JP;
Masaharu Torikai, Kumamoto, JP;
Tomoyo Takeo, Kumamoto, JP;
Masayo Ueno, Kumamoto, JP;
Hirofumi Higuchi, Kikuchi, JP;
Kenji Soejima, Kumamoto, JP;
Toshihiro Nakashima, Kumamoto, JP;
Yukio Ando, Kumamoto, JP;
Hirofumi Jono, Kumamoto, JP;
Yu Su, Shanghai, CN;
KM BIOLOGICS CO., LTD., Kumamoto, JP;
NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, Kumamoto, JP;
Abstract
A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.