The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
May. 07, 2018
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Carl H. June, Merion Station, PA (US);
Bruce L. Levine, Cherry Hill, NJ (US);
Michael D. Kalos, Philadelphia, PA (US);
Stephan Grupp, Havertown, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Abstract
The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need thereof a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain and monitoring the levels of cytokines in the patient post T cell infusion to determine the type of second-line of therapy appropriate for treating the patient as a consequence of the presence of the CAR T cell in the patient.