The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2020
Filed:
Dec. 29, 2011
Beatrice Maria Arico, Poggibonsi, IT;
Brunella Brunelli, Grosseto, IT;
Maurizio Comanducci, Castelnuovo Berardenga, IT;
Mariagrazia Pizza, Siena, IT;
Silvana Savino, Taverna Val di Pesa, IT;
Maria Scarselli, Siena, IT;
Beatrice Maria Arico, Poggibonsi, IT;
Brunella Brunelli, Grosseto, IT;
Maurizio Comanducci, Castelnuovo Berardenga, IT;
Mariagrazia Pizza, Siena, IT;
Silvana Savino, Taverna Val di Pesa, IT;
Maria Scarselli, Siena, IT;
GLAXOSMITHKLINE BIOLOGICAL SA, Rixensart, BE;
Abstract
The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.